Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial

Table 2 Neuroimaging data acquisition parameters

Sequence	Main parameters [orientation, TR/TE/TI, FOV, slices, voxel size]
Structural sequences
T1 MPRAGE	Sagittal, TR/TE/TI = 1900/2.52/900 ms, 256 × 256 mm², 192 slices, 1.0 × 1.0 × 1.0 mm³
FLAIR	Axial, TR/TE = 11,000/97 ms, 230 × 230 mm², 50 slices, 1.2 × 1.2 × 2.5 mm³
DTI	Axial, TR/TE = 7500/86 ms, 220 × 220 mm², 61 slices, 2.3 × 2.3 × 2.3 mm³, 64 directions (b = 1000)
High-resolution hippocampus TSE	Coronar, TR/TE = 8020/48 ms, 150 × 150mm², 24 slices, 0.4 × 0.4 × 2.0 mm³
Functional sequences
Resting-state fMRI	Axial, TR/TE = 2300/30 ms, 192 × 192 mm², 34 slices, 3.0 × 3.0 × 4.0 mm³
Task-related fMRI	Axial, TR/TE = 2000/30 ms, 192 × 192 mm², 32 slices, 3.0 × 3.0 × 3.0 mm³
pCASL	Axial, TR/TE = 4300/19 ms, 192 × 192 mm², 22 slices, 3.0 × 3.0 × 5.0 mm³, LD/PLD = 1.5/1.5 s

Abbreviations: DTI diffusion tensor imaging, FLAIR fluid-attenuated inversion recovery, fMRI functional magnetic resonance imaging, FOV field of view, LD labeling duration, MPRAGE magnetization-prepared rapid acquisition gradient echo, pCASL pseudo-continuous arterial spin labeling, PLD post-label delay, TE echo time, TI inversion time, TR repetition time, TSE turbo spin echo