Skip to main content

Advertisement

Table 4 Predictors of death and institution over the follow-up, multivariable Cox regression analyses

From: CSF level of β-amyloid peptide predicts mortality in Alzheimer’s disease

Characteristics Death Institutionalization
HR (95% CI) P value HR (95% CI) P value
Age, yeara 1.66 (1.21–2.28) 0.002 1.11 (0.86–1.44) 0.44
Men vs women 2.11 (1.19–3.76) 0.01 1.56 (0.94–2.59) 0.09
Level of educationb
 Low Ref. Ref.
 Intermediate 1.21 (0.58–2.52) 0.61 2.45 (1.25–4.83) 0.009
 High 1.02 (0.45–2.31) 0.96 1.45 (0.68–3.09) 0.33
MMSE scorec 1.56 (1.16–2.10) 0.003 1.68 (1.29–2.18) < 0.001
APOE ε4 allele
 0 Ref. Ref.
 1 0.79 (0.43–1.44) 0.44 1.00 (0.58–1.73) 0.98
 2 0.59 (0.25–1.36) 0.21 0.70 (0.32–1.52) 0.37
Collection tube, before 2012 vs recent 1.37 (0.60–3.01) 0.46 0.74 (0.36–1.52) 0.41
CSF Aβ42, pg/mLc 1.89 (1.25–2.86) 0.002 0.89 (0.60–1.32) 0.55
CSF tau, pg/mLa 1.11 (0.84–1.48) 0.45 0.99 (0.78–1.26) 0.96
  1. aContinuous, estimate for 1 standard deviation increase
  2. bLow: primary school or less, intermediate: secondary to high school, high: baccalaureate or university degree
  3. cContinuous, estimate for 1 standard deviation decrease