Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

Table 3 Logistic regression analysis of rs8019381 C/T SNP on the AD phenotype considering for age, gender, and APOE ε4 allele

Coefficients of bias-reduced logistic regression
Variable	Parameter	Standard error	Wald χ²	P value
Intercept	− 13.917	1.528	− 9.107	< 0.0001
Age	0.179	0.020	8.750	< 0.0001
Gender	− 0.051	0.416	− 0.123	0.902
APOE ε4 allele^a	1.691	0.403268658	4.194	0.000033
rs8019381 genotype^b	3.078	0.968	3.181	0.00157

^aFor APOE ε4 allele analyses, ε4 non-carriers were coded as 0 and APOE ε4 carriers were coded as 1
^bFor rs8019381 genotype analyses, each SNP was coded as 0 for major allele homozygotes, 0.5 for heterozygotes, and 1 for minor allele homozygotes

ISSN: 1758-9193