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Table 2 Distribution of the NRXN3 rs8019381 C/T SNP and APOE allele frequencies among the rs8019381 genotypes

From: Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

Group Genotypea Allele frequency P value
CC CT TT C T
rs8019381 genotype and allele frequenciesb
 Control (n = 336) 291 (0.866) 43 (0.128) 2 (0.006) 0.930 0.070 Genotype: P = 0.00041 (X2 = 15.6, df = 2) Allele: P = 0.000063 (X2 = 16.0, df = 1)
 AD (n = 121) 86 (0.711) 32 (0.264) 3 (0.025) 0.843 0.157
rs8019381 genotypes among APOE ε4 non-carriers and APOE ε4 carriers
 Control APOE ε4 non-carriers 216 (0.857) 35 (0.139) 1 (0.004) 0.927 0.073 APOE ε4 non-carriers VS.ε4 carriers in the AD Genotype: P = 0.018 (X2 = 8.0, df = 2) Allele: P = 0.000063 (X2 = 0.43, df = 1)
APOE ε4 carriers 75 (0.893) 8 (0.095) 1 (0.012) 0.940 0.060
 AD APOE ε4 non-carriers 26 (0.722) 7 (0.195) 3 (0.083) 0.819 0.181
APOE ε4 carriers 60 (0.706) 25 (0.294) 0 (0.000) 0.853 0.147
  1. aNumber of subjects (frequency)
  2. brs8019381: Significant differences were found between the AD and the controls in either the genotype distribution (χ2 = 15.587, df = 2, P = 0.000413) or the allele frequencies (χ2 = 15.997, df = 1, P = 0.0000634)