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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

Fig. 4

a–c Expression levels of mRNAs encoding NRXN3 transmembrane isoforms (exon 22a-24a, exon 22a-24b, and exon 22a-24c variants, respectively) and d NRXN3 soluble isoform (exon 22a-23a variant) in the middle frontal gyrus of control individuals (n = 44 individuals with rs8019381 CC genotype) and AD patients (n = 35 individuals with rs8019381 CC genotype and n = 23 individuals with CT or TT genotypes). Relative levels of each mRNA expression were obtained after normalization to GAPDH. Then, percentile change is obtained respective to an average of β-NRXN3 mRNA in control individuals with CC genotype. *P < 0.05, **P < 0.001, ***P < 0.0001, calculated using two-tailed Mann-Whitney tests

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Alzheimer's Research & Therapy

ISSN: 1758-9193