Model/predictors | OR | (95% CI) | p value | R 2 | ΔR2 | OR | (95% CI) | p value | R 2 | ΔR2 | ||
Model variables | Abnormal CSF-Aβ42 (< 813 pg/ml) | Abnormal CSF-tau (> 375 pg/ml) | ||||||||||
Step 1: covariates | ||||||||||||
Age (per 1-year increase) | 1.09 | 1.03–1.15 | 0.003 | 0.080 | 0.080 | 1.18 | 1.09–1.28 | < 0.001 | 0.187 | 0.187 | ||
Positive APOE ε4 status | 2.34 | 1.10–5.00 | 0.028 | 0.126 | 0.046 | 6.20 | 2371–16.2 | < 0.001 | 0.329 | 0.142 | ||
Step 2: center (ADC = reference) | 0.001 | 0.271 | 0.145 | 0.562 | 0.339 | 0.010 | ||||||
DELCODE | 6.54 | 2.14–20.0 | 0.001 | 0.841 | 0.241–2.94 | 0.786 | ||||||
IDIBAPS | 5.78 | 2.14–15.6 | 0.001 | 1.53 | 0.476–4.89 | 0.477 | ||||||
Model variables | Abnormal CSF-ptau181 (> 53 pg/ml) | Abnormal Aβ42 and abnormal ptau181 | ||||||||||
Step 1: covariates | ||||||||||||
Age (per 1-year increase) | Not selected | 1.15 | 1.05–1.26 | 0.002 | 0.117 | 0.117 | ||||||
Positive APOE ε4 status | 2.66 | 1.28–5.54 | 0.009 | 0.069 | 0.069 | 5.23 | 1.80–15.2 | 0.002 | 0.234 | 0.117 | ||
Step 2: center (ADC = reference) | 0.728 | 0.075 | 0.006 | 0.393 | 0.255 | 0.021 | ||||||
DELCODE | 0.983 | 0.401–2.41 | 0.970 | 1.68 | 0.374–7.54 | 0.499 | ||||||
IDIBAPS | 1352 | 0.574–3.19 | 0.490 | 2.60 | 0.643–10.5 | 0.180 |