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Table 3 Brain regions showing statistically significant gray matter volumetric decrease in pairwise comparisons between non-SCD, SCD+, and SCD– groups

From: Brain and cognitive correlates of subjective cognitive decline-plus features in a population-based cohort

Contrast   Label MNI coordinates Cluster Peak pFWE-corr
x y z size Z score Peak Cluster
SCD– > SCD+ Cluster 1 Left temporal middle −59 −33 −12 345 4.13 0.117 0.459
Left temporal inferior        
Cluster 2 Left temporal inferior −33 −15 −44 801 4.05 0.151 0.164
Left fusiform        
Cluster 3 Left temporal pole superior −38 −11 −17 753 3.81 0.315 0.182
Left temporal middle        
Left temporal superior        
Left temporal pole middle        
Cluster 4 Right cerebellum 30 −74 −20 734 3.73 0.393 0.190
Right Fusiform        
Cluster 5 Left postcentral −53 −20 30 208 3.72 0.401 0.625
Left supramarginal        
Cluster 7 Right cerebellum 12 −66 −47 556 3.72 0.403 0.283
Vermis        
Cluster 8 Vermis −2 −59 −18 1540 3.68 0.437 0.037
Left cerebellum        
Left fusiform        
Right cerebellum        
Cluster 9 Left cerebellum −14 −68 −45 559 3.63 0.494 0.281
Cluster 10 Left occipital superior −17 −77 29 340 3.59 0.536 0.464
Left precuneus        
Left cuneus        
Cluster 11 Right temporal inferior 47 −9 −38 420 3.59 0.541 0.386
Right temporal pole        
Right fusiform        
Cluster 12 Left temporal superior −54 −45 15 428 3.54 0.593 0.379
Left temporal middle        
SCD– > non-SCD Cluster 1 Left temporal pole superior −45 6 −17 4502 4.66 0.015 0.000
Left fusiform        
Left temporal pole middle        
Left temporal superior        
Left hippocampus        
Left parahippocampal        
Left insula        
Left amygdala        
Cluster 2 Left cuneus −17 −63 33 2216 4.56 0.022 0.011
Left occipital superior        
Left precuneus        
Right cuneus        
Left calcarine        
Cluster 3 Right fusiform 30 −77 −17 956 4.31 0.061 0.118
Right cerebellum        
Right lingual        
Right occipital inferior        
Cluster 4 Left lingual 2 −57 −18 3020 4.28 0.068 0.003
Vermis        
Left cerebellum        
Left fusiform        
Cluster 5 Right temporal pole middle 39 9 −33 1723 4.15 0.109 0.026
Right temporal inferior        
Right temporal pole superior        
Cluster 6 Right frontal inferior 50 2 20 1157 4.11 0.126 0.078
Right rolandic        
Right precentral        
Cluster 7 Left temporal middle −59 −33 −12 317 3.99 0.183 0.489
Left temporal inferior        
Cluster 8 Left occipital middle −32 −75 15 123 3.93 0.220 0.749
Cluster 9 Right supramarginal 45 −30 33 189 3.72 0.404 0.651
Right postcentral        
Cluster 10 Left temporal superior −59 −35 12 250 3.58 0.551 0.569
Left temporal middle        
Cluster 11 Left postcentral −53 −17 32 396 3.58 0.554 0.408
Left parietal inferior        
Left supramarginal        
Cluster 12 Right cerebellum −3 −68 −45 489 3.56 0.601 0.330
Left cerebellum        
Cluster 13 Left rolandic −60 −3 12 229 3.53 0.624 0.596
Left postcentral        
Cluster 14 Right occipital superior 26 −71 33 109 3.40 0.617 0.771
  1. non-SCD not self-reporting cognitive decline, SCD– SCD with ≤ 3 SCDplus features, SCD+ SCD with > 3 SCDplus features, SCDplus subjective cognitive decline plus, MNI Montreal Neurological Institute, pFWE Family-wise Error-adjusted p-value