Treatment groups | No. of animals | Mean value | ± SEM | Effect size | p value | |
---|---|---|---|---|---|---|
Amyloid β immunohistochemistry total area cortex (μm2) | ||||||
Non-immunotolerized | Ctrl-IgG1 | 8 | 696,471 | 81,813 | ||
Immunotolerized | Ctrl-IgG1 | 9 | 569,092 | 63,738 | −18% vs non-immunotolerized | NS |
Immunotolerized | SAR228810 | 8 | 207,996 | 27,252 | −63% vs immunotolerized DM4 | < 0.001 |
Immunotolerized | SAR255952 | 8 | 197,600 | 17,064 | −65% vs immunotolerized DM4 | < 0.001 |
Cystatin F mRNA hippocampus (related units) | ||||||
Non-immunotolerized | Ctrl-IgG1 | 12 | 78 | 7.5 | ||
Immunotolerized | Ctrl-IgG1 | 12 | 80 | 8.9 | + 3% vs non-immunotolerized | NS |
Immunotolerized | SAR228810 | 12 | 24 | 3.2 | −70% vs immunotolerized DM4 | < 0.001 |
Immunotolerized | SAR255952 | 9 | 28 | 2.8 | −66% vs immunotolerized DM4 | < 0.001 |