Fig. 5
![Fig. 5](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13195-018-0447-y/MediaObjects/13195_2018_447_Fig5_HTML.png)
In-vivo penetration of SAR255952 in brain parenchyma and long-lasting binding to amyloid plaques in the cortex of APPSL mice. a Successive imaging sessions performed prior to and following the i.v. administration of SAR255952 labeled with Dyelight-649 (red); amyloid plaques labeled by Methoxy-XO4 (green). b Higher magnification image showing that SAR255952 (red) decorates Aβ plaques (green) 144 h after i.v. administration. c Quantification of temporal changes in the antibody-DyeLight-649 fluorescence showing that SAR255952 accumulates on amyloid plaques while being cleared from the parenchyma. **p <0.01 , ***p <0.005 , versus . n.s. not significant