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Table 1 Demographics of cerebrospinal fluid donors

From: Preanalytical approaches to improve recovery of amyloid-β peptides from CSF as measured by immunological or mass spectrometry-based assays

  CSF collection, aliquoting, and storage protocol used to evaluate effect of aliquot volume and tube type on Aβ1–42 recovery Comparison of CSF collection, aliquoting, and storage protocols used to evaluate effect of GuHCl timing on Aβ recovery
YNC AD YNC DEM
No. of subjects 20 82 10 10
Age, years, mean (SD) 36 (5.9) 72 (8.4) 30 (10) 68 (6.3)
Male, n (%) 11 (55%) 33 (40%) 6 (60%) 5 (50%)
Female, n (%) 9 (45%) 49 (60%) 4 (40%) 5 (50%)
MMSE score (SD) NA 21 (0.80) NA 20 (2.2)
  1. Abbreviations: Aβ Amyloid-β, AD Alzheimer’s disease, CSF Cerebrospinal fluid, DEM Dementia of unknown origin, GuHCl Guanidine hydrochloride, MMSE Mini Mental State Examination, YNC Young normal control subjects