Table 2 Hazard ratios and 95% confidence intervals of all-cause dementia, Alzheimer’s disease, and vascular dementia by quartiles of metabolic parameter variability measured as coefficient of variation
From: Variability in metabolic parameters and risk of dementia: a nationwide population-based study
|  | All-cause dementia | Alzheimer’s disease | Vascular dementia | ||||||
|---|---|---|---|---|---|---|---|---|---|
Events (n) | Incidence rate (per 1000 person-years) | HR (95% CI) | Events (n) | Incidence rate (per 1000 person-years) | HR (95% CI) | Events (n) | Incidence rate (per 1000 person-years) | HR (95% CI) | |
Body mass index | |||||||||
 Q1 | 5818 | 1.50 | 1 (ref.) | 4338 | 1.12 | 1 (ref.) | 661 | 0.17 | 1 (ref.) |
 Q2 | 6264 | 1.59 | 1.07 (1.03–1.11) | 4694 | 1.19 | 1.07 (1.03–1.12) | 691 | 0.18 | 1.04 (0.94–1.16) |
 Q3 | 7443 | 1.90 | 1.13 (1.09–1.17) | 5497 | 1.41 | 1.11 (1.06–1.15) | 845 | 0.22 | 1.17 (1.06–1.30) |
 Q4 | 13,376 | 3.49 | 1.41 (1.36–1.45) | 9957 | 2.60 | 1.36 (1.31–1.41) | 1432 | 0.37 | 1.51 (1.38–1.66) |
P for trend |  | < 0.001 |  |  | < 0.001 |  |  | < 0.001 | |
Systolic blood pressure | |||||||||
 Q1 | 7058 | 1.81 | 1 (ref.) | 5208 | 1.34 | 1 (ref.) | 795 | 0.20 | 1 (ref.) |
 Q2 | 6586 | 1.71 | 1.02 (0.99–1.05) | 4900 | 1.27 | 1.03 (0.99–1.07) | 719 | 0.19 | 0.99 (0.89–1.09) |
 Q3 | 7607 | 1.94 | 1.03 (1.00–1.07) | 5647 | 1.44 | 1.04 (1.00–1.08) | 890 | 0.23 | 1.08 (0.98–1.19) |
 Q4 | 11,650 | 3.02 | 1.15 (1.12–1.18) | 8731 | 2.26 | 1.15 (1.11–1.19) | 1225 | 0.32 | 1.16 (1.06–1.27) |
P for trend |  | < 0.001 |  |  | < 0.001 |  |  | < 0.001 | |
Glucose | |||||||||
 Q1 | 7388 | 1.94 | 1 (ref.) | 5449 | 1.43 | 1 (ref.) | 821 | 0.22 | 1 (ref.) |
 Q2 | 7483 | 1.93 | 1.04 (1.01–1.08) | 5568 | 1.43 | 1.06 (1.02–1.10) | 837 | 0.22 | 1.04 (0.94–1.14) |
 Q3 | 8030 | 2.05 | 1.06 (1.03–1.09) | 5983 | 1.53 | 1.07 (1.03–1.11) | 914 | 0.23 | 1.08 (0.98–1.18) |
 Q4 | 10,000 | 2.54 | 1.12 (1.08–1.15) | 7486 | 1.90 | 1.13 (1.09–1.17) | 1057 | 0.27 | 1.08 (0.99–1.19) |
P for trend |  | < 0.001 |  |  | < 0.001 |  |  | 0.076 | |
Total cholesterol | |||||||||
 Q1 | 7468 | 1.94 | 1 (ref.) | 5589 | 1.45 | 1 (ref.) | 805 | 0.21 | 1 (ref.) |
 Q2 | 7420 | 1.89 | 1.07 (1.03–1.10) | 5477 | 1.40 | 1.05 (1.01–1.09) | 832 | 0.21 | 1.09 (0.99–1.20) |
 Q3 | 7835 | 2.00 | 1.09 (1.06–1.13) | 5896 | 1.51 | 1.10 (1.06–1.14) | 873 | 0.22 | 1.12 (1.02–1.23) |
 Q4 | 10,178 | 2.64 | 1.21 (1.18–1.25) | 7524 | 1.95 | 1.19 (1.15–1.24) | 1119 | 0.29 | 1.26 (1.15–1.38) |
P for trend |  | < 0.001 |  |  | < 0.001 |  |  | < 0.001 | |