| |
Whole sample rho(p value)
|
CTRrho(p value)
|
MCrho(p value)
|
AMCrho(p value)
|
SMCrho(p value)
|
|---|
|
N (N CSF)
|
60 (35)
|
18 (10)
|
42 (25)
|
20 (8)
|
22 (17)
|
|
Age
|
0.58 (< 0.001)
|
0.03 (0.92)
|
0.64 (< 0.001)
|
0.35 (0.13)
|
0.31 (0.16)
|
|
EYO
|
0.65 (< 0.001)
|
−0.25 (0.31)
|
0.75 (< 0.001)
|
0.41 (0.07)
|
0.29 (0.19)
|
|
MMSE
|
−0.65 (< 0.001)
|
0.24 (0.34)
|
−0.77 (< 0.001)
|
−0.30 (0.13)
|
−0.48 (0.02)
|
|
CDR-SOB
|
0.62 (< 0.001)
|
na
|
0.70 (< 0.001)
|
na
|
0.35 (0.18)
|
|
CSF NfL
|
0.70 (< 0.001)
|
0.22 (0.58)
|
0.72 (< 0.001)
|
0.66 (0.16)
|
0.41 (0.17)
|
|
CSF Aβ1–42
|
−0.43 (0.01)
|
0.04 (0.91)
|
−0.32 (0.12)
|
0.24 (0.57)
|
0.33 (0.19)
|
|
CSF total tau
|
0.59 (< 0.001)
|
−0.68 (0.03)
|
0.71 (< 0.001)
|
0.19 (0.65)
|
0.39 (0.12)
|
|
CSF p-tau
|
0.60 (< 0.001)
|
−0,56 (0.09)
|
0,71 (< 0.001)
|
0.19 (0.65)
|
0.41 (0.10)
|
- Significant results are indicated in bold typeface
- AMC asymptomatic mutation carriers, CTR non-carriers, CDR-SOB Clinical Dementia Rating sum of boxes, CSF cerebrospinal fluid, EYO estimated years from symptom onset, MC mutation carriers, MMSE Mini-Mental State Examination, na not applicable, NfL neurofilament light, p-tau phosphorylated tau, SMC symptomatic mutation carriers
