Table 1 Participant demographics, cognitive test scores, serum and CSF NfL, and CSF Alzheimer’s disease marker concentrations
CTR | AMC | SMC | K-W | CTR vs SMC | CTR vs AMC | SMC vs AMC | |
|---|---|---|---|---|---|---|---|
M-W U (z; p) | M-W U (z; p) | M-W U (z; p) | |||||
N = 60 (N CSF = 35) | 18 (10) | 20 (8) | 22 (17) | ||||
Age (years), mean (SD) | 36.28 (8.51) | 34.24 (8.81) | 49.16 (10.00) | p < 0.001 | 57 (–3.83; < 0.001) | 145 (–1.02; 0.38) | 55 (–4.15; < 0.001) |
Sex, M/F | 7/10 | 4/17 | 9/13 | na | na | na | na |
EYO (years), mean (SD) | -8.22 (7.9) | -14.26 (7.68) | 4.12 (2.52) | p < 0.001 | 20 (–8.40; < 0.001) | 106 (–2.16; 0.03) | 0 (–5.54; < 0.001) |
MMSE, mean (SD) | 29.17 (1,04) | 29.35 (0,93) | 19.14 (5.46) | p < 0.001 | 3 (–5.34; < 0.001) | 198 (0.58; 0.61) | 2.5 (–5.55; < 0.001) |
CDR, mean (SD) | 0 | 0 | 1.27 (0.82) | p < 0.001 | 0 (–5.36; < 0.001) | na | 0 (–5.36; < 0.001) |
CDR-SOB, mean (SD) | 0 | 0 | 5.69 (4.15) | p < 0.001 | 0 (–5.39; < 0.001) | na | 0 (–5.39; < 0.001) |
Serum NfL (ng/L), mean (SD) | 13.85 (5.63) | 12.43 (6.48) | 30.87 (15.14) | p < 0.001 | 39 (–4.32; < 0.001) | 142 (–1.11; 0.27) | 39 (–4.56; < 0.001) |
CSF NfL (ng/L), mean (SD) | 526.53 (198.89) | 517.50 (85.02) | 2123.19 (649.45) | p < 0.001 | 1 (–3.84; < 0.001) | 31 (–0.53; 1) | 0 (–3.60; < 0.001) |
CSF Aβ1–42 (ng/L), mean (SD) | 753.98 (231.97) | 950.52 (542.67) | 327.46 (136.71) | p < 0.001 | 3 (–4.12, < 0.001) | 49 (0.80; 0.46) | 12 (–3.26; < 0.001) |
CSF total tau (ng/L), mean (SD) | 233.70 (73.48) | 243.23 (52.12) | 1166.60 (958.79) | p < 0.001 | 2 (–4.17; < 0.001) | 40 (0.00; 1) | 0 (–3.96; < 0.001) |
CSF p-tau (ng/L), mean (SD) | 44.63 (10.92) | 49.25 (11.00) | 153.34 (132.26) | p < 0.001 | 9 (–3.82; < 0.001) | 50.50 (0.93;0.36) | 12 (–3.26; < 0.001) |