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Table 1 Participant demographics, cognitive test scores, serum and CSF NfL, and CSF Alzheimer’s disease marker concentrations

From: Serum neurofilament light levels correlate with severity measures and neurodegeneration markers in autosomal dominant Alzheimer’s disease

  CTR AMC SMC K-W CTR vs SMC CTR vs AMC SMC vs AMC
M-W U (z; p) M-W U (z; p) M-W U (z; p)
N = 60 (N CSF = 35) 18 (10) 20 (8) 22 (17)     
Age (years), mean (SD) 36.28 (8.51) 34.24 (8.81) 49.16 (10.00) p < 0.001 57 (–3.83; < 0.001) 145 (–1.02; 0.38) 55 (–4.15; < 0.001)
Sex, M/F 7/10 4/17 9/13 na na na na
EYO (years), mean (SD) -8.22 (7.9) -14.26 (7.68) 4.12 (2.52) p < 0.001 20 (–8.40; < 0.001) 106 (–2.16; 0.03) 0 (–5.54; < 0.001)
MMSE, mean (SD) 29.17 (1,04) 29.35 (0,93) 19.14 (5.46) p < 0.001 3 (–5.34; < 0.001) 198 (0.58; 0.61) 2.5 (–5.55; < 0.001)
CDR, mean (SD) 0 0 1.27 (0.82) p < 0.001 0 (–5.36; < 0.001) na 0 (–5.36; < 0.001)
CDR-SOB, mean (SD) 0 0 5.69 (4.15) p < 0.001 0 (–5.39; < 0.001) na 0 (–5.39; < 0.001)
Serum NfL (ng/L), mean (SD) 13.85 (5.63) 12.43 (6.48) 30.87 (15.14) p < 0.001 39 (–4.32; < 0.001) 142 (–1.11; 0.27) 39 (–4.56; < 0.001)
CSF NfL (ng/L), mean (SD) 526.53 (198.89) 517.50 (85.02) 2123.19 (649.45) p < 0.001 1 (–3.84; < 0.001) 31 (–0.53; 1) 0 (–3.60; < 0.001)
CSF Aβ1–42 (ng/L), mean (SD) 753.98 (231.97) 950.52 (542.67) 327.46 (136.71) p < 0.001 3 (–4.12, < 0.001) 49 (0.80; 0.46) 12 (–3.26; < 0.001)
CSF total tau (ng/L), mean (SD) 233.70 (73.48) 243.23 (52.12) 1166.60 (958.79) p < 0.001 2 (–4.17; < 0.001) 40 (0.00; 1) 0 (–3.96; < 0.001)
CSF p-tau (ng/L), mean (SD) 44.63 (10.92) 49.25 (11.00) 153.34 (132.26) p < 0.001 9 (–3.82; < 0.001) 50.50 (0.93;0.36) 12 (–3.26; < 0.001)
  1. Significant results are indicated in bold typeface
  2. AMC asymptomatic mutation carriers, CTR non-carriers, CDR Clinical Dementia Rating, CDR-SOB Clinical Dementia Rating sum of boxes, CSF cerebrospinal fluid, EYO estimated years from symptom onset, K-W Kruskal-Wallis test, M/F male/female, MMSE Mini-Mental State Examination, M-W U Mann-Whitney U test, na not applicable, NfL neurofilament light, p-tau phosphorylated tau, SD standard deviation, SMC symptomatic mutation carriers