Table 4 Imaging recommendations for EPAD longitudinal cohort study
From: Secondary prevention of Alzheimer’s dementia: neuroimaging contributions
Imaging technique | Baseline | Baseline use | Follow-up | Follow-up use | Measures |
|---|---|---|---|---|---|
3D T1 | Standard | Exclusion criteria Volumetric analysis Visual rating pathology Identify increased risk of decline | Annually | New incidental findings Atrophy rates Track visual pathology Identify increased risk of decline | Volumetric analysis: brain structures Visual: lacunes, atrophy |
3D FLAIR | Standard | Exclusion criteria Volumetric analysis Visual rating pathology Subject stratification | Annually | New incidental findings Track visual pathology | Volumetric analysis: white matter hyperintensities Visual: lacunes, white matter hyperintensities, ARIA |
2D-T2 | Standard | Exclusion criteria Visual rating pathology | Annually | New incidental findings Track visual pathology | Visual: lacunes, perivascular spaces, ARIA |
2D-T2* 3D-T2*/ SWI | Standard Optional | Exclusion criteria Visual rating pathology | Annually | New incidental findings Track visual pathology | Visual: microbleeds and superficial siderosis |
DTI | Optional | Exploratory analysis | Optional 2-year | Changes in measures | Axial and radial diffusivity |
ASL | Optional | Exploratory analysis | Optional 2-year | Changes in measures | Whole brain and regional perfusion |
rs-fMRI | Optional | Exploratory analysis | Optional 2-year | Changes in measures | Connectivity measures |
Amyloid PET (static and dynamic) | Optional | Inclusion criteria | Optional | Changes in measures | Visual: amyloid positive Quantitative measures of amyloid pathology Dynamic scanning: perfusion measures |