Skip to main content

Table 4 Imaging recommendations for EPAD longitudinal cohort study

From: Secondary prevention of Alzheimer’s dementia: neuroimaging contributions

Imaging technique Baseline Baseline use Follow-up Follow-up use Measures
3D T1 Standard Exclusion criteria
Volumetric analysis
Visual rating pathology
Identify increased risk of decline
Annually New incidental findings
Atrophy rates
Track visual pathology
Identify increased risk of decline
Volumetric analysis: brain structures
Visual: lacunes, atrophy
3D FLAIR Standard Exclusion criteria
Volumetric analysis
Visual rating pathology
Subject stratification
Annually New incidental findings
Track visual pathology
Volumetric analysis: white matter hyperintensities
Visual: lacunes, white matter hyperintensities, ARIA
2D-T2 Standard Exclusion criteria
Visual rating pathology
Annually New incidental findings
Track visual pathology
Visual: lacunes, perivascular spaces, ARIA
2D-T2*
3D-T2*/ SWI
Standard
Optional
Exclusion criteria
Visual rating pathology
Annually New incidental findings
Track visual pathology
Visual: microbleeds and superficial siderosis
DTI Optional Exploratory analysis Optional
2-year
Changes in measures Axial and radial diffusivity
ASL Optional Exploratory analysis Optional
2-year
Changes in measures Whole brain and regional perfusion
rs-fMRI Optional Exploratory analysis Optional
2-year
Changes in measures Connectivity measures
Amyloid PET (static and dynamic) Optional Inclusion criteria Optional Changes in measures Visual: amyloid positive
Quantitative measures of amyloid pathology
Dynamic scanning: perfusion measures
  1. ARIA Amyloid-related imaging abnormalities, ASL arterial spin labelling, DTI diffusion tensor imaging, EPAD European Prevention for Alzheimer’s Dementia, FLAIR fluid attenuated inversion recovery, PET positron emission tomography, rs-fMRI resting state functional magnetic resonance imaging