Fig. 4

Moderations of functional connectivity on the effect of white matter lesions (WML) on cognition. Regression line plots showing the mean predicted scores of cognition on two levels of functional connectivity (FC), high (1 SD) and low (–1 SD) on WML. a The negative impact of WML on executive functions was reduced in individuals with higher levels of global functional connectivity in the fronto-parietal network. A similar moderation effect was not found for memory. b The local connectivity cluster from the salience network extracted as the multiple regression between our behavioral measure of cognitive reserve and the anterior cingulate cortex seed (p < 0.005, FDR corrected). Regression line plots show a significant moderation of local functional connectivity in the salience network on the negative impact of WML on executive functions and a trend for memory. Shaded area indicates 80% confidence intervals; p values of the interaction terms are displayed for each graph. LPFC lateral prefrontal cortex, PPC posterior parietal cortex