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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Neurophysiological signals as predictive translational biomarkers for Alzheimer’s disease treatment: effects of donepezil on neuronal network oscillations in TgF344-AD rats

Fig. 4

Power spectral density of spontaneous cortical EEGs in aged wild-type (WT) and TgF344-AD rats. Donepezil significantly increases spectral density (F(3.1 × 10–5,2.5 × 10–5) = 1.88; p < 0.0001, two-way ANOVA) in the WT frontal cortex (a), and significantly decreases spectral density (F(3.1 × 10–5,2.5 × 10–5) = 1.81; p < 0.0001, two-way ANOVA) in the TgF344-AD frontal cortex (b). Donepezil has no significant impact on spectral density in the occipital cortex for either WT or TgF344-AD

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Alzheimer's Research & Therapy

ISSN: 1758-9193