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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Neurophysiological signals as predictive translational biomarkers for Alzheimer’s disease treatment: effects of donepezil on neuronal network oscillations in TgF344-AD rats

Fig. 3

Effect of donepezil on spontaneous paroxysmal high-voltage spindles (HVSs) in the cortex of aged wild-type (WT) and TgF344-AD rats. a,b Example traces and spectrograms of 10 min of spontaneous frontal cortex EEG from WT and TgF344-AD rats at baseline and after donepezil injection. Large negative deflections in the EEG and prominent bouts of high power activity between 6 and 9 Hz in the spectrogram are HVS events. c,d Group effect of donepezil (1 mg/kg) injection on HVSs in WT and TgF344-AD rats. e,f Group effect of diazepam (1 mg/kg) injection on HVSs in WT and TgF344-AD rats

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Alzheimer's Research & Therapy

ISSN: 1758-9193