Fig. 1
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13195-018-0431-6/MediaObjects/13195_2018_431_Fig1_HTML.png)
Schematic drawing of QC inhibitor approach. pGlu-Aβ is posttranslationally formed by QC from N-terminally truncated Aβ versions carrying a glutamate at position N3 and N11. pGlu-Aβ seeds Aβ oligomers which are highly synaptotoxic and neurotoxic. Aβ amyloid beta, pGlu pyroglutamate, QC glutaminyl cyclase, sAPPβ soluble amyloid precursor protein beta