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Table 2 Visual rating scores according to diagnosis and amyloid status

From: MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study

Score Cognitively normal Mild cognitive impairment Alzheimer-type dementia
Amyloid negative Amyloid positive Amyloid negative Amyloid positive Amyloid negative Amyloid positive
MTA 0 (0–1) 0 (0–1) 0.5 (0–1) 1 (0.5–1.5)†† 1 (0.5–2) 1 (1–2)
GCA 0 (0–1) 0 (0–1) 0 (0–1) 1 (0–1)†† 1 (0–2) 1 (1–1)
Parietal 1 (0–1) 0.5 (0–1) 1 (0–1) 1 (0–1.63) 2 (0–2) 1 (1–2)
Fazekas 1 (0–1) 1 (0–1) 1 (0–1) 1 (1–2) 1 (1–1) 1 (0–2)
Microbleeds present 6 (21%) 4 (20%) 29 (25%) 56 (29%) 1 (50%) 17 (22%)
  1. Data presented as median (interquartile range) or count (%)
  2. APOE apolipoprotein E, FDR false discovery rate, GCA global cortical atrophy, MTA medial temporal lobe atrophy
  3. pFDR < 0.05, ††pFDR < 0.01, difference between amyloid positive and negative within diagnostic group. Analyses corrected for age, gender, APOE ε4 genotype and cohort