Skip to main content

Advertisement

Table 1 Baseline characteristics by diagnosis and amyloid status

From: MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study

Characteristic Cognitively normal Mild cognitive impairment Alzheimer-type dementia
Amyloid negative Amyloid positive Amyloid negative Amyloid positive Amyloid negative Amyloid positive
N, % within diagnosis 245 (73) 92 (27) 140 (37) 235 (63) 3 (3) 95 (97)
Age (years) 66.1 ± 7.2 67.5 ± 7.2 67.3 ± 8.0 70.2 ± 7.0*** 63.1 ± 8.0 67.1 ± 7.7
Male gender 120 (49) 47 (51) 73 (52) 105 (45) 3 (100) 48 (51)
Education (years) 13.2 ± 3.5 12.8 ± 3.8 10.8 ± 4.0 11.1 ± 3.7 10.3 ± 5.1 11.1 ± 3.3
MMSE 28.9 ± 1.2 28.8 ± 1.2 27.1 ± 2.2 26.0 ± 2.6*** 27.7 ± 1.2 22.4 ± 4.0**
Memory immediate 0.10 ± 1.00 0.08 ± 1.10 − 0.64 ± 1.32 −1.22 ± 1.44*** −0.45 ± 0.91 −2.25 ± 1.06
Memory delayed 0.25 ± 1.01 0.30 ± 1.09 −0.90 ± 1.29 − 1.37 ± 1.41** −0.96 ± 1.33 − 2.28 ± 1.04
Language −0.21 ± 1.01 0.01 ± 1.04 −0.65 ± 1.30 −0.88 ± 1.27 −0.76 ± 0.38 −1.95 ± 1.02*
Attention 0.32 ± 1.03 0.26 ± 0.89 −0.74 ± 1.79 −0.81 ± 1.63 0.54 ± 0.52 − 2.03 ± 1.94*
Executive functioning 0.35 ± 1.09 0.12 ± 1.15 − 0.76 ± 1.89 −1.11 ± 1.98* 0.46 ± 0.32 −2.49 ± 2.46*
Visuo-construction − 0.23 ± 1.36 − 0.19 ± 1.20 0.18 ± 1.46 −0.30 ± 1.66* −0.59 ± 2.09 −1.30 ± 2.00
APOE ε4 genotype 89 (36) 53 (58)*** 27 (19) 160 (66)*** 2 (67) 66 (69)
Available markers
 Visual 245 (100) 92 (100) 140 (100) 235 (100) 3 (100) 95 (100)
 Subcortical volumes 240 (98) 90 (98) 130 (93) 230 (98)* 2 (67) 89 (94)
 Cortical thickness 232 (95) 88 (96) 119 (85) 200 (85) 2 (67) 88 (93)
  1. Data presented as mean ± standard deviation or count (%). Demographic characteristics based on maximum available data (visual rating)
  2. APOE apolipoprotein E, MMSE Mini-Mental State Examination
  3. *p < 0.05, **p < 0.01, ***p < 0.001, difference between amyloid positive and negative within diagnostic group