Fig. 3

Power analysis in the cognitively normal group. To assess the effect of including inter-network connectivity as an inclusion criterion in clinical trials, we performed a power analysis in the cognitively normal group. The x axis describes the memory slope reduction in percentages and the y axis describes the number of participants needed per arm to detect this reduction with 80% power and α = 0.05 in a 4-year trial with annual assessments. The green line shows the sample size needed when only amyloid is used as an inclusion criterion and inter-network connectivity between the DMN and DAN is not considered. The orange line shows the required sample size when positive inter-network correlations between the DMN and DAN and amyloid are used as inclusion criteria. The blue line shows the required sample size when negative inter-network correlations between the DMN and DAN and amyloid are used as inclusion criteria