Fig. 5

Intra-ECN functional connectivity relates to memory and executive/attention in subjects with cerebrovascular disease and to memory in subjects without cerebrovascular disease. Representative regions showing associations between intra-ECN functional connectivity and cognition. a In AD and aMCI subjects without CeVD, higher frontoparietal FC between rPPC and right middle superior frontal gyrus was associated with better verbal memory. In AD and aMCI subjects with CeVD, b higher frontal FC between lDLPFC and right middle frontal gyrus was associated with worse executive function, c higher parietal FC between rPPC and left inferior parietal gyrus was associated with better attention function, and d higher frontoparietal FC between lPPC and right superior frontal gyrus was associated with better visual memory. All FC cognitions shown pass the multiple comparisons correction for number of cognitive domains at p < 0.0125. AD Alzheimer’s disease, aMCI amnestic mild cognitive impairment, CeVD cerebrovascular disease, DLPFC dorsolateral prefrontal cortex, DMN default mode network, ECN executive control network, FC functional connectivity, IPG inferior parietal gyrus, l left, MFG middle frontal gyrus, PPC posterior parietal cortex, r right, SFG superior frontal gyrus,