Fig. 1

Mean PiB retention and FDG uptake SUVRs. a AD_PiB-ROI between FH^– and FH⁺. b AD_PiB-ROI between APOE4^– and APOE4⁺. c AD_FDG-ROI between FH^– and FH⁺. d AD_FDG-ROI between APOE^– and APOE⁺. e Interaction effect of FH and APOE on PiB retention. f Interaction effect of FH and APOE on FDG uptake. The green shaded area in e denotes below the PiB SUVR threshold of 1.4. Error bars indicate standard error. *P < 0.05; **significant difference in the post-hoc analyses adjusted for multiple comparisons using Dunn-Sidak correction (P_B < 0.0085). Aβ amyloid beta, APOE4 apolipoprotein ε4 allele, APOE4⁺ APOE4 carriers, APOE4^– APOE4 noncarriers, FDG [¹⁸F] fluoro-2-deoxyglucose, FH family history of Alzheimer’s disease, FH⁺ individuals with FH, FH^– individuals without FH, L left hemisphere, PiB [¹¹C] Pittsburg compound B, R right hemisphere, SUVR standardized uptake value ratio