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Table 3 Table of genome-wide significant G×G interactions with rQTL

From: Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels

Trait rQTL SNP2 Chrom Location Maj/Min (MAF) p value Gene Left gene Right gene
Aβ42 rs8027714 rs57134082 12 40057892 T/A (0.166) < 5 × 10 –9 C12orf40 ABCD2 SLC2A13
tau rs74025622 rs9817620 b 3 261440 T/C (0.062) 1.50 × 10 –8 CHL1 LOC642891 LOC402123
tau rs74025622 rs73105331a,b 7 52374812 C/T (0.031) 3.00 × 10–8   LOC107986796 LOC107986738
tau rs74025622 rs75034965b 22 35710231 G/A (0.144) 3.75 × 10–8 TOM1 HMGXB4 HMOX1
p-tau rs689167 rs1558634 7 29553339 C/T (0.125) 1.00 × 10 –8 CHN2 NANOGP4 LOC646745
p-tau rs79099429 a,c rs79688703 b 16 7899349 T/C (0.059) 5.00 × 10 –9   RBFOX1 LOC105371069
p-tau rs15205a,c rs79688703b 16 7899349 T/C (0.059) 2.75 × 10–8   RBFOX1 LOC105371069
  1. p values based on 100 million parametric bootstraps
  2. SNPs and p values in bold are significant after correcting for the number of independent and significant ptau/Aβ42 rQTL (p < 1 × 10−8); those underlined are significant after correcting for the tau/Aβ42 rQTL (p < 1.67 × 10−8); the rest are not mentioned in the text and are suggestive
  3. Chrom Chromosome, G×G gene-by-gene, MAF minor allele frequency, Maj Major Allele, Min Minor Allele, rQTL relationship quantitative trait loci, SNP single nucleotide polymorphism
  4. aNominally significant for rate of decline
  5. bNominally significant for Aβ42 G×G
  6. cNominally significant for direct association with Aβ42