|
Trait
|
rQTL
|
SNP2
|
Chrom
|
Location
|
Maj/Min (MAF)
|
p value
|
Gene
|
Left gene
|
Right gene
|
|---|
|
Aβ42
|
rs8027714
|
rs57134082
|
12
|
40057892
|
T/A (0.166)
|
< 5 × 10
–9
|
C12orf40
|
ABCD2
|
SLC2A13
|
|
tau
|
rs74025622
|
rs9817620
b
|
3
|
261440
|
T/C (0.062)
|
1.50 × 10
–8
|
CHL1
|
LOC642891
|
LOC402123
|
|
tau
|
rs74025622
|
rs73105331a,b
|
7
|
52374812
|
C/T (0.031)
|
3.00 × 10–8
| |
LOC107986796
|
LOC107986738
|
|
tau
|
rs74025622
|
rs75034965b
|
22
|
35710231
|
G/A (0.144)
|
3.75 × 10–8
|
TOM1
|
HMGXB4
|
HMOX1
|
|
p-tau
|
rs689167
|
rs1558634
|
7
|
29553339
|
C/T (0.125)
|
1.00 × 10
–8
|
CHN2
|
NANOGP4
|
LOC646745
|
|
p-tau
|
rs79099429
a,c
|
rs79688703
b
|
16
|
7899349
|
T/C (0.059)
|
5.00 × 10
–9
| |
RBFOX1
|
LOC105371069
|
|
p-tau
|
rs15205a,c
|
rs79688703b
|
16
|
7899349
|
T/C (0.059)
|
2.75 × 10–8
| |
RBFOX1
|
LOC105371069
|
- p values based on 100 million parametric bootstraps
- SNPs and p values in bold are significant after correcting for the number of independent and significant ptau/Aβ42 rQTL (p < 1 × 10−8); those underlined are significant after correcting for the tau/Aβ42 rQTL (p < 1.67 × 10−8); the rest are not mentioned in the text and are suggestive
- Chrom Chromosome, G×G gene-by-gene, MAF minor allele frequency, Maj Major Allele, Min Minor Allele, rQTL relationship quantitative trait loci, SNP single nucleotide polymorphism
- aNominally significant for rate of decline
- bNominally significant for Aβ42 G×G
- cNominally significant for direct association with Aβ42
