| Control | Dementia | bvFTD | nfvPPA | svPPA | lvPPA | PPA-NOS |
---|---|---|---|---|---|---|---|
No. of subjects | 17 | 64 | 20 | 16 | 11 | 14 | 3 |
Male sex, n (% group) | 6 (54.5) | 45 (70.3) | 19 (95.0) | 9 (56.2) | 7 (63.6) | 7 (50.0) | 3 (100.0) |
Age at CSF collection, years, mean (SD) | 63.7 (6.4) | 64.6 (6.5) | 63.4 (7.1) | 66.9 (5.9) | 60.8 (6.0) | 66.5 (6.0) | 64.6 (5.4) |
Age at onset, years, mean (SD) | n/a | 59.5 (6.9) | 56.1 (6.7) | 62.7 (6.1) | 56.1 (5.3) | 63.0 (6.7) | 61.3 (4.1) |
Disease duration at CSF collection, years, mean (SD); median (IQR) | n/a | 5.1 (3.8); 4.2 (2.7–6.3) | 7.4 (5.6); 6.3 (3.4–8.8) | 4.2 (1.9); 4.2 (2.8–5.1) | 4.7 (2.1); 4.6 (3.4–6.3) | 3.5 (2.0); 3.1 (1.9–4.8) | 3.2 (1.3); 2.7 (2.3–4.7) |
CSF sTREM2, ng/ml, mean (SD) | 6.8 (1.6) | 7.4 (3.2) | 6.3 (3.7) | 7.8 (2.2) | 7.4 (2.4) | 8.2 (4.1) | 8.7 (1.9) |
CSF Aβ42, pg/ml, mean (SD) | 1032.2 (214.3) | 758.1 (280.7) | 828.3 (171.7) | 842.5 (298.0) | 894.0 (247.4) | 444.6 (148.3) | 804.3 (434.2) |
CSF T-tau, pg/ml, mean (SD) | 332.6 (82.4) | 531.4 (404.5) | 351.9 (135.5) | 490.6 (247.8) | 395.5 (200.3) | 968.8 (617.0) | 403.3 (208.5) |
CSF P-tau, pg/ml, mean (SD) | 52.7 (10.6) | 57.0 (30.6) | 45.7 (17.0) | 50.6 (18.1) | 44.9 (19.8) | 91.7 (41.6) | 49.0 (14.4) |
CSF T-tau/Aβ42 ratio, median (IQR) | 0.3 (0.2–0.5) | 0.5 (0.3–1.0) | 0.4 (0.3–0.5) | 0.6 (0.3–0.9) | 0.4 (0.3–0.5) | 2.0 (1.1–3.2) | 0.4 (0.2–1.2) |