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Table 1 Demographics and cerebrospinal fluid biomarker levels of control and dementia groups and all clinical subgroups

From: Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup

  Control Dementia bvFTD nfvPPA svPPA lvPPA PPA-NOS
No. of subjects 17 64 20 16 11 14 3
Male sex, n (% group) 6 (54.5) 45 (70.3) 19 (95.0) 9 (56.2) 7 (63.6) 7 (50.0) 3 (100.0)
Age at CSF collection, years, mean (SD) 63.7 (6.4) 64.6 (6.5) 63.4 (7.1) 66.9 (5.9) 60.8 (6.0) 66.5 (6.0) 64.6 (5.4)
Age at onset, years, mean (SD) n/a 59.5 (6.9) 56.1 (6.7) 62.7 (6.1) 56.1 (5.3) 63.0 (6.7) 61.3 (4.1)
Disease duration at CSF collection, years, mean (SD); median (IQR) n/a 5.1 (3.8); 4.2 (2.7–6.3) 7.4 (5.6); 6.3 (3.4–8.8) 4.2 (1.9); 4.2 (2.8–5.1) 4.7 (2.1); 4.6 (3.4–6.3) 3.5 (2.0); 3.1 (1.9–4.8) 3.2 (1.3); 2.7 (2.3–4.7)
CSF sTREM2, ng/ml, mean (SD) 6.8 (1.6) 7.4 (3.2) 6.3 (3.7) 7.8 (2.2) 7.4 (2.4) 8.2 (4.1) 8.7 (1.9)
CSF Aβ42, pg/ml, mean (SD) 1032.2 (214.3) 758.1 (280.7) 828.3 (171.7) 842.5 (298.0) 894.0 (247.4) 444.6 (148.3) 804.3 (434.2)
CSF T-tau, pg/ml, mean (SD) 332.6 (82.4) 531.4 (404.5) 351.9 (135.5) 490.6 (247.8) 395.5 (200.3) 968.8 (617.0) 403.3 (208.5)
CSF P-tau, pg/ml, mean (SD) 52.7 (10.6) 57.0 (30.6) 45.7 (17.0) 50.6 (18.1) 44.9 (19.8) 91.7 (41.6) 49.0 (14.4)
CSF T-tau/Aβ42 ratio, median (IQR) 0.3 (0.2–0.5) 0.5 (0.3–1.0) 0.4 (0.3–0.5) 0.6 (0.3–0.9) 0.4 (0.3–0.5) 2.0 (1.1–3.2) 0.4 (0.2–1.2)
  1. n/a Not applicable; for others, see list of abbreviations