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Table 1 Demographics and cerebrospinal fluid biomarker levels of control and dementia groups and all clinical subgroups

From: Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup

 

Control

Dementia

bvFTD

nfvPPA

svPPA

lvPPA

PPA-NOS

No. of subjects

17

64

20

16

11

14

3

Male sex, n (% group)

6 (54.5)

45 (70.3)

19 (95.0)

9 (56.2)

7 (63.6)

7 (50.0)

3 (100.0)

Age at CSF collection, years, mean (SD)

63.7 (6.4)

64.6 (6.5)

63.4 (7.1)

66.9 (5.9)

60.8 (6.0)

66.5 (6.0)

64.6 (5.4)

Age at onset, years, mean (SD)

n/a

59.5 (6.9)

56.1 (6.7)

62.7 (6.1)

56.1 (5.3)

63.0 (6.7)

61.3 (4.1)

Disease duration at CSF collection, years, mean (SD); median (IQR)

n/a

5.1 (3.8); 4.2 (2.7–6.3)

7.4 (5.6); 6.3 (3.4–8.8)

4.2 (1.9); 4.2 (2.8–5.1)

4.7 (2.1); 4.6 (3.4–6.3)

3.5 (2.0); 3.1 (1.9–4.8)

3.2 (1.3); 2.7 (2.3–4.7)

CSF sTREM2, ng/ml, mean (SD)

6.8 (1.6)

7.4 (3.2)

6.3 (3.7)

7.8 (2.2)

7.4 (2.4)

8.2 (4.1)

8.7 (1.9)

CSF Aβ42, pg/ml, mean (SD)

1032.2 (214.3)

758.1 (280.7)

828.3 (171.7)

842.5 (298.0)

894.0 (247.4)

444.6 (148.3)

804.3 (434.2)

CSF T-tau, pg/ml, mean (SD)

332.6 (82.4)

531.4 (404.5)

351.9 (135.5)

490.6 (247.8)

395.5 (200.3)

968.8 (617.0)

403.3 (208.5)

CSF P-tau, pg/ml, mean (SD)

52.7 (10.6)

57.0 (30.6)

45.7 (17.0)

50.6 (18.1)

44.9 (19.8)

91.7 (41.6)

49.0 (14.4)

CSF T-tau/Aβ42 ratio, median (IQR)

0.3 (0.2–0.5)

0.5 (0.3–1.0)

0.4 (0.3–0.5)

0.6 (0.3–0.9)

0.4 (0.3–0.5)

2.0 (1.1–3.2)

0.4 (0.2–1.2)

  1. n/a Not applicable; for others, see list of abbreviations