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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup

Fig. 3

Relationship between CSF sTREM2 levels and age and disease duration at CSF collection. Graphs show CSF sTREM2 versus age (a) and disease duration (b and c) at CSF collection for the whole cohort (a, dotted line), dementia and control groups (a and b), and dementia subgroups defined by CSF biomarker status (c). Lines in (a) are group regression lines adjusted for sex (whole cohort and controls) and sex and disease duration (dementia group). Line in (b) is group regression line for dementia group adjusted for age and sex. Lines in (c) are group regression lines adjusted for age and sex for each CSF biomarker-defined dementia subgroup. AD biomarker-negative dementia: CSF T-tau/Aβ42 ratio < 1.0; AD biomarker-positive dementia: CSF T-tau/Aβ42 ratio > 1.0. See main text for individual β and P values for each association. Aβ42 β-Amyloid 1–42, AD Alzheimer’s disease, bvFTD Behavioural variant frontotemporal dementia, CSF Cerebrospinal fluid, lvPPA Logopenic variant primary progressive aphasia, nfvPPA Non-fluent variant primary progressive aphasia, PPA-NOS Primary progressive aphasia not otherwise specified, sTREM2 Soluble triggering receptor expressed on myeloid cells 2, svPPA Semantic variant primary progressive aphasia, T-tau Total tau

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