Table 1 Patient characteristics
APOE ε4-negative (n = 19) | APOE ε4-positive (n = 46) | P value | |
|---|---|---|---|
Diagnosis, n (MCI due to AD/AD dementia) | 4/15 | 18/28 | 0.27 |
Age (years) | 70.1 ± 7.8 | 72.4 ± 6.8 | 0.23 |
Sex, n (male/female) | 9/10 | 18/28 | 0.29 |
Education, years | 11.1 ± 2.7 | 12.5 ± 3.4 | 0.13 |
APOE genotype | ε3/ε3 (n = 19) | ε2/ε4 (n = 3) ε3/ε4 (n = 27) ε4/ε4 (n = 16) | NA |
CSF Aβ42, ng/L | 405 ± 97 | 405 ± 104 | 0.99 |
CSF T-tau, ng/L | 855 ± 366 | 673 ± 283 | 0.035 |
CSF P-tau, ng/L | 105 ± 4 | 81 ± 31 | 0.012 |
WML, mL | 15.5 (13.8) | 11.9 (14.0) | 0.31 |
Hippocampal volume, mL | 2968 (576) | 2907 (442) | 0.50 |
MMSE | 22.2 ± 5.8 | 22.6 ± 4.3 | 0.73 |
ADAS immediate recall | 5.9 ± 1.8 | 5.9 ± 1.3 | 0.98 |
ADAS delayed recall | 6.2 ± 3.1 | 8.0 ± 2.01 | 0.018 |
TMT-A | 123.6 ± 112.0 | 75.0 ± 42.5 | 0.021 |
AQT-CF | 102.9 ± 27.6 | 91.2 ± 38.5 | 0.35 |
Fluency—animals | 9.9 ± 6.8 | 12.1 ± 5.2 | 0.21 |
Fluency—letter (S) | 8.0 ± 5.6 | 11.1 ± 4.9 | 0.055 |