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Table 3 Structural neuroanatomical associations of sine-wave speech comprehension in the patient cohort

From: Retained capacity for perceptual learning of degraded speech in primary progressive aphasia and Alzheimer’s disease

Contrast Region Cluster (voxels) Peak (mm) t Score p Value
x y z
Sine-wave numbers Angular gyrus 12 − 38 − 54 46 4.63 0.045
Sine-wave place names Planum temporale 377 − 52 − 34 12 5.19 0.013
Angular gyrus 25 − 39 − 54 48 4.74 0.035
Place names > numbers Temporal pole 383 − 46 18 − 34 5.03 0.018
Numbers > place names Inferior frontal gyrus 84 − 45 16 4 4.70 0.037
Perceptual learning: sine-wave numbers Post-central gyrus 175 − 38 − 33 54 5.26 0.011
Post-central gyrus 627 − 58 − 20 38 4.96 0.021
  1. The table summarises statistically significant (positive) associations between regional grey matter volume and the relevant performance measure for the processing of sine-wave speech stimuli (see text for details), based on a voxel-based morphometric analysis of brain magnetic resonance images for the combined patient cohort. All local maxima presented are significant at p < 0.05FWE within a pre-specified left hemispheric ROI (see Additional file 5). Coordinates of local maxima are in Montreal Neurological Institute (MNI) standard space