Retained capacity for perceptual learning of degraded speech in primary progressive aphasia and Alzheimer’s disease

Table 3 Structural neuroanatomical associations of sine-wave speech comprehension in the patient cohort

Contrast	Region	Cluster (voxels)	Peak (mm)			t Score	p Value
Contrast	Region	Cluster (voxels)	x	y	z	t Score	p Value
Sine-wave numbers	Angular gyrus	12	− 38	− 54	46	4.63	0.045
Sine-wave place names	Planum temporale	377	− 52	− 34	12	5.19	0.013
Sine-wave place names	Angular gyrus	25	− 39	− 54	48	4.74	0.035
Place names > numbers	Temporal pole	383	− 46	18	− 34	5.03	0.018
Numbers > place names	Inferior frontal gyrus	84	− 45	16	4	4.70	0.037
Perceptual learning: sine-wave numbers	Post-central gyrus	175	− 38	− 33	54	5.26	0.011
Perceptual learning: sine-wave numbers	Post-central gyrus	627	− 58	− 20	38	4.96	0.021

The table summarises statistically significant (positive) associations between regional grey matter volume and the relevant performance measure for the processing of sine-wave speech stimuli (see text for details), based on a voxel-based morphometric analysis of brain magnetic resonance images for the combined patient cohort. All local maxima presented are significant at p < 0.05_FWE within a pre-specified left hemispheric ROI (see Additional file 5). Coordinates of local maxima are in Montreal Neurological Institute (MNI) standard space

ISSN: 1758-9193