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Table 4 Association of amyloid-β levels with incident dementia in carriers and non-carriers of apolipoprotein ε4 allele

From: Plasma amyloid-β levels, cerebral atrophy and risk of dementia: a population-based study

Plasma Aβ levels (per SD increase)

Incident dementia (n = 79)

HR (95% CI)a

APOE-ε4 carriers (n = 35)

APOE-ε4 non-carriers (n = 44)

Aβ1–38

1.58 (1.01–2.89) b

1.10 (0.66–1.83)

Aβ1–40

1.03 (0.58–1.83)

1.04 (0.64–1.71)

Aβ1–42

1.07 (0.76–1.52)

1.47 (1.09–1.99) b

Aβ1–40/Aβ1–42 ratio

0.72 (0.41–1.26)

0.75 (0.45–1.16)

  1. Abbreviations: Aβ amyloid-β, SD standard deviation, HR hazard ratio, CI confidence interval, APOE Apolipoprotein
  2. a Adjusted for age, sex, education, mean arterial blood pressure, total cholesterol, diabetes, smoking and other Aβ levels
  3. bSignificant at p <0.05
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Alzheimer's Research & Therapy

ISSN: 1758-9193