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Table 2 Values of neurodegenerative markers by Aβ/WMH groups

From: Correction to: Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline

 

Aβ- WMH-

Aβ- WMH+

Aβ + WMH-

Aβ + WMH+

Neurodegeneration markers

n = 140

n = 39

n = 63

n = 29

MTA score

1.2 (1.2)B,C,D

2.6 (1.6)A,D

2.1 (1.6)A,D

3.4 (1.8)A,B,C

 MTA abnormal, n

62 (45)B,C,D

32 (82)A

41 (67)A,D

26 (93)A,C

P-tau, pg/ml

54.5 (27.7)C

63.2 (29.3)

77.0 (56.3)A

65.2 (38.2)

 P-tau abnormal, n

53 (38)C

22 (58)

45 (71)A

15 (52)

T-tau, pg/ml

314.7 (202.0)B,C,D

438.4 (248.0)A

499.3 (413.8)A

426.2 (275.2)A

 T-tau abnormal, n

36 (26)B,C,D

20 (53)A

36 (57)A

14 (48)A

  1. Results are mean (SD) and number (%). All analyses were adjusted for study, baseline diagnosis and demographics
  2. Abbreviations: amyloid-beta, MTA medial temporal lobe atrophy, P-tau phosphorylated tau, T-tau Total tau, WMH white matter hyperintensities
  3. Ap < 0.05 compared to Aβ- WMH-
  4. Bp < 0.05 compared to Aβ- WMH+.
  5. Cp < 0.05 compared to Aβ + WMH-.
  6. Dp < 0.05 compared to Aβ + WMH+.