Fig. 1

Case examples of fibrillar amyloid burden and corresponding [¹⁸F]flutemetamol PET images from subjects in [2, 7]. Histopathology samples from all eight cortical regions were in agreement. Examples are taken from frontal sections except for row C, column 2 (4G8 IHC), a digital magnification showing diffuse amyloid plaques in the precuneus. Column 1: Bielschowsky silver staining (BSS) of neuritic plaques. Column 2: 4G8 Aβ immunohistochemistry (neuritic and diffuse Aβ plaques). Column 3: Axial [¹⁸F]flutemetamol PET. Column 4: Sagittal [¹⁸F]flutemetamol PET. Row A: True positive case (case 91 in [7]): 80-year-old male assessed as PET-positive by majority read (5/5 readers). Row B: True negative case (case 38 in [7]): 86-year-old male assessed as PET-negative by majority read (5/5 readers). Row C: False positive case (case 43 in [7]): 86-year-old female assessed as PET-positive by majority read (5/5 readers)