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Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementia

Fig. 6

Active immunotherapy using tau294–305 epitope to hepatitis B core immunodominant region (T294-HBc) virus-like particle (VLP) vaccine reduced astrogliosis in Tau.P301S mice. Astrogliosis in brain of mice treated with or without vaccine and of wild-type (WT) mice was detected by IHC and Western blotting with anti-glial fibrillary acidic protein (anti-GFAP) antibody. The astrogliosis in brain (a), cortex (b), and hippocampal CA1 (c) and dentate gyrus (DG) regions (d) was quantified by morphometric analysis. e GFAP levels detected by Western blot analysis. The Western blotting signals were quantified using IPwin5 Image-Pro Plus software, and GAPDH was used as a control. Scale bar is 200 μm (compared with adjuvant-treated mice; *P < 0.05, **P < 0.01, Student’s t test)

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Alzheimer's Research & Therapy

ISSN: 1758-9193