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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementia

Fig. 5

The effect of tau294–305 epitope to hepatitis B core immunodominant region (T294-HBc) virus-like particle (VLP) immunization on the levels of insoluble tau in Tau.P301S. The radioimmunoprecipitation assay buffer (RIPA)-insoluble tau in mouse brain homogenates was subjected to SDS-PAGE and then transferred onto nitrocellulose membrane. The tau protein was probed by human tau-specific antibody HT7 (1:3000) (a) and total tau antibody tau 5 (1:2000) (b), respectively. The Western blot signals were quantified using IPwin5 Image-Pro Plus software, and β-actin was used as a control (compared with adjuvant-treated Tau.P301S mice; *P < 0.05, Student’s t test)

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Alzheimer's Research & Therapy

ISSN: 1758-9193