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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody

Fig. 1

Global antibody distribution in the brain. Brain distribution in 18-month-old tg-ArcSwe mice given an injection with [125I]RmAb158-scFv8D3 (a) and [125I]RmAb158 (b), 6 days postinjection, as visualized with ex vivo autoradiography (left) in comparison with amyloid-β 40 immunostaining (right). Whereas [125I]RmAb158-scFv8D3 was distributed throughout the whole brain, [125I]RmAb158 was confined to central parts of the brain. For comparison, also wild-type animals were given an injection with [125I]RmAb158-scFv8D3, resulting in no signal (c) and with [125I]RmAb158, where a faint signal was detected centrally in the brain (d)

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Alzheimer's Research & Therapy

ISSN: 1758-9193