Distinct patterns of brain atrophy in Genetic Frontotemporal Dementia Initiative (GENFI) cohort revealed by visual rating scales

Table 1 Demographic data and visual rating scores

	Control subjects	GRN	C9ORF72	MAPT	Total	GRN	C9ORF72	MAPT	Total	Significance
	Control subjects	Presymptomatic				Symptomatic				Significance
Number	148	66	42	24	132	17	31	15	63
Age	48.86 (14.32)	49.55 (10.90)	44.66 (11.49)	38.70 (8.80)	46.02 (11.42)	63.96 (5.70)	65.92 (7.61)	57.17 (8.21)	63.31 (8.02)	^a^,b^,c^,d,e,g
Sex	90 M	41 M	25 M	14 M	80 M	11 M	9 M	4 M	24 M	^c,d,e,f
Sex	58 F	25 F	17 F	10 F	52 F	6 F	22 F	11 F	39 F	^c,d,e,f
OF	0.19 (0.33)	0.20 (0.35)	0.33 (0.55)	0.28 (0.70)	0.26 (0.50)	1.99 (0.55)	1.54 (0.72)	1.43 (0.70)	1.63 (0.70)	^b^,c^,d*^,e,f
AC	0.35 (0.37)	0.46 (0.49)	0.45 (0.49)	0.38 (0.65)	0.44 (0.52)	2.09 (0.69)	1.65 (0.69)	1.35 (0.52)	1.69 (0.70)	^b^,c^,d*^,f
AT	0.22 (0.35)	0.30 (0.38)	0.30 (0.48)	0.31 (0.72)	0.30 (0.48)	1.53 (0.57)	1.44 (0.71)	2.38 (0.93)	1.69 (0.82)	^b^,c^,d*^,f,g
FI	0.61 (0.47)	0.64 (0.47)	0.66 (0.64)	0.49 (0.55)	0.62 (0.54)	2.24 (0.42)	2.10 (0.50)	1.80 (0.52)	2.07 (0.50)	^b^,c^,d*^,f
MTA	0.28 (0.41)	0.31 (0.40)	0.45 (0.74)	0.51 (0.74)	0.39 (0.60)	1.40 (0.64)	1.82 (1.10)	2.60 (1.28)	1.89 (1.12)	^a,b^,c^,d*^,f
PA	0.36 (0.52)	0.33 (0.52)	0.42 (0.59)	0.18 (0.25)	0.33 (0.51)	1.79 (0.77)	1.66 (0.72)	0.77 (0.55)	1.48 (0.80)	^b^,c^,d,f^,g
ASYMM	1.49 (0.90)	1.79 (1.20)	1.62 (1.08)	1.50 (0.92)	1.68 (1.11)	4.41 (2.00)	2.92 (1.23)	2.20 (0.88)	3.15 (1.62)	^b^,c^,d,e,f*^,g

Abbreviations: GRN Progranulin, C9ORF72 Chromosome 9 open reading frame 72, MAPT Microtubule-associated protein tau, OF Orbitofrontal rating scale, AC Anterior cingulate rating scale, AT Anterior temporal rating scale, FI Frontoinsula rating scale, MTA Medial temporal atrophy rating scale, PA Posterior atrophy rating scale, ASYMM Asymmetry index
Data are reported as mean (SD). The t test was used for age and education, the χ² was used for sex, and the Mann-Whitney U test was used for visual rating scales
^aControls vs Presymtomatic MAPT
^bControls vs Symptomatic GRN
^cControls vs Symptomatic C9ORF72
^dControls vs Symptomatic MAPT
^eSymptomatic GRN vs Symptomatic MAPT
^fSymptomatic GRN vs Symptomatic C9ORF72
^gSymptomatic C9ORF72 vs Symptomatic MAPT
* P < 0.001; otherwise, P < 0.05

ISSN: 1758-9193