| |
Control subjects
|
GRN
|
C9ORF72
|
MAPT
|
Total
|
GRN
|
C9ORF72
|
MAPT
|
Total
|
Significance
|
|---|
|
Presymptomatic
|
Symptomatic
|
|---|
|
Number
|
148
|
66
|
42
|
24
|
132
|
17
|
31
|
15
|
63
| |
|
Age
|
48.86 (14.32)
|
49.55 (10.90)
|
44.66 (11.49)
|
38.70 (8.80)
|
46.02 (11.42)
|
63.96 (5.70)
|
65.92 (7.61)
|
57.17 (8.21)
|
63.31 (8.02)
|
a*,b*,c*,d,e,g*
|
|
Sex
|
90 M
|
41 M
|
25 M
|
14 M
|
80 M
|
11 M
|
9 M
|
4 M
|
24 M
|
c,d,e,f
|
|
58 F
|
25 F
|
17 F
|
10 F
|
52 F
|
6 F
|
22 F
|
11 F
|
39 F
|
|
OF
|
0.19 (0.33)
|
0.20 (0.35)
|
0.33 (0.55)
|
0.28 (0.70)
|
0.26 (0.50)
|
1.99 (0.55)
|
1.54 (0.72)
|
1.43 (0.70)
|
1.63 (0.70)
|
b*,c*,d*,e,f
|
|
AC
|
0.35 (0.37)
|
0.46 (0.49)
|
0.45 (0.49)
|
0.38 (0.65)
|
0.44 (0.52)
|
2.09 (0.69)
|
1.65 (0.69)
|
1.35 (0.52)
|
1.69 (0.70)
|
b*,c*,d*,f
|
|
AT
|
0.22 (0.35)
|
0.30 (0.38)
|
0.30 (0.48)
|
0.31 (0.72)
|
0.30 (0.48)
|
1.53 (0.57)
|
1.44 (0.71)
|
2.38 (0.93)
|
1.69 (0.82)
|
b*,c*,d*,f,g
|
|
FI
|
0.61 (0.47)
|
0.64 (0.47)
|
0.66 (0.64)
|
0.49 (0.55)
|
0.62 (0.54)
|
2.24 (0.42)
|
2.10 (0.50)
|
1.80 (0.52)
|
2.07 (0.50)
|
b*,c*,d*,f
|
|
MTA
|
0.28 (0.41)
|
0.31 (0.40)
|
0.45 (0.74)
|
0.51 (0.74)
|
0.39 (0.60)
|
1.40 (0.64)
|
1.82 (1.10)
|
2.60 (1.28)
|
1.89 (1.12)
|
a,b*,c*,d*,f
|
|
PA
|
0.36 (0.52)
|
0.33 (0.52)
|
0.42 (0.59)
|
0.18 (0.25)
|
0.33 (0.51)
|
1.79 (0.77)
|
1.66 (0.72)
|
0.77 (0.55)
|
1.48 (0.80)
|
b*,c*,d,f*,g*
|
|
ASYMM
|
1.49 (0.90)
|
1.79 (1.20)
|
1.62 (1.08)
|
1.50 (0.92)
|
1.68 (1.11)
|
4.41 (2.00)
|
2.92 (1.23)
|
2.20 (0.88)
|
3.15 (1.62)
|
b*,c*,d,e,f*,g
|
- Abbreviations: GRN Progranulin, C9ORF72 Chromosome 9 open reading frame 72, MAPT Microtubule-associated protein tau, OF Orbitofrontal rating scale, AC Anterior cingulate rating scale, AT Anterior temporal rating scale, FI Frontoinsula rating scale, MTA Medial temporal atrophy rating scale, PA Posterior atrophy rating scale, ASYMM Asymmetry index
- Data are reported as mean (SD). The t test was used for age and education, the χ2 was used for sex, and the Mann-Whitney U test was used for visual rating scales
- aControls vs Presymtomatic MAPT
- bControls vs Symptomatic GRN
- cControls vs Symptomatic C9ORF72
- dControls vs Symptomatic MAPT
- eSymptomatic GRN vs Symptomatic MAPT
- fSymptomatic GRN vs Symptomatic C9ORF72
- gSymptomatic C9ORF72 vs Symptomatic MAPT
- * P < 0.001; otherwise, P < 0.05
