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Table 1 Demographic data and visual rating scores

From: Distinct patterns of brain atrophy in Genetic Frontotemporal Dementia Initiative (GENFI) cohort revealed by visual rating scales

  Control subjects GRN C9ORF72 MAPT Total GRN C9ORF72 MAPT Total Significance
Presymptomatic Symptomatic
Number 148 66 42 24 132 17 31 15 63  
Age 48.86 (14.32) 49.55 (10.90) 44.66 (11.49) 38.70 (8.80) 46.02 (11.42) 63.96 (5.70) 65.92 (7.61) 57.17 (8.21) 63.31 (8.02) a*,b*,c*,d,e,g*
Sex 90 M 41 M 25 M 14 M 80 M 11 M 9 M 4 M 24 M c,d,e,f
58 F 25 F 17 F 10 F 52 F 6 F 22 F 11 F 39 F
OF 0.19 (0.33) 0.20 (0.35) 0.33 (0.55) 0.28 (0.70) 0.26 (0.50) 1.99 (0.55) 1.54 (0.72) 1.43 (0.70) 1.63 (0.70) b*,c*,d*,e,f
AC 0.35 (0.37) 0.46 (0.49) 0.45 (0.49) 0.38 (0.65) 0.44 (0.52) 2.09 (0.69) 1.65 (0.69) 1.35 (0.52) 1.69 (0.70) b*,c*,d*,f
AT 0.22 (0.35) 0.30 (0.38) 0.30 (0.48) 0.31 (0.72) 0.30 (0.48) 1.53 (0.57) 1.44 (0.71) 2.38 (0.93) 1.69 (0.82) b*,c*,d*,f,g
FI 0.61 (0.47) 0.64 (0.47) 0.66 (0.64) 0.49 (0.55) 0.62 (0.54) 2.24 (0.42) 2.10 (0.50) 1.80 (0.52) 2.07 (0.50) b*,c*,d*,f
MTA 0.28 (0.41) 0.31 (0.40) 0.45 (0.74) 0.51 (0.74) 0.39 (0.60) 1.40 (0.64) 1.82 (1.10) 2.60 (1.28) 1.89 (1.12) a,b*,c*,d*,f
PA 0.36 (0.52) 0.33 (0.52) 0.42 (0.59) 0.18 (0.25) 0.33 (0.51) 1.79 (0.77) 1.66 (0.72) 0.77 (0.55) 1.48 (0.80) b*,c*,d,f*,g*
ASYMM 1.49 (0.90) 1.79 (1.20) 1.62 (1.08) 1.50 (0.92) 1.68 (1.11) 4.41 (2.00) 2.92 (1.23) 2.20 (0.88) 3.15 (1.62) b*,c*,d,e,f*,g
  1. Abbreviations: GRN Progranulin, C9ORF72 Chromosome 9 open reading frame 72, MAPT Microtubule-associated protein tau, OF Orbitofrontal rating scale, AC Anterior cingulate rating scale, AT Anterior temporal rating scale, FI Frontoinsula rating scale, MTA Medial temporal atrophy rating scale, PA Posterior atrophy rating scale, ASYMM Asymmetry index
  2. Data are reported as mean (SD). The t test was used for age and education, the χ2 was used for sex, and the Mann-Whitney U test was used for visual rating scales
  3. aControls vs Presymtomatic MAPT
  4. bControls vs Symptomatic GRN
  5. cControls vs Symptomatic C9ORF72
  6. dControls vs Symptomatic MAPT
  7. eSymptomatic GRN vs Symptomatic MAPT
  8. fSymptomatic GRN vs Symptomatic C9ORF72
  9. gSymptomatic C9ORF72 vs Symptomatic MAPT
  10. * P < 0.001; otherwise, P < 0.05