|  |  | Amyloid-β42 (ng/L) Analyzed in 2012 | Amyloid-β42 (ng/L) Analyzed in 2017 | T-tau (ng/L) | P-tau (ng/L) |
|---|
1995 | Brother A (age 44 yr) |
321
|
453
| 156 | 37 |
Brother B (age 43 yr) | 652 | N.A. | 136 | 26 |
2006 | Brother A (age 55 yr) | 730 |
421
|
704
|
82
|
Brother B (age 54 yr) | 1914 | 1256 | 212 | 41 |
- Abbreviations: CSF Cerebrospinal fluid, N.A. Not available, P-tau Phosphorylated tau, T-tau Total tau
- Biomarker levels that fall outside the reference range are highlighted in bold. The normal values for these three biomarkers applied at the Clinical Neurochemistry Laboratory at the Sahlgrenska University Hospital in Mölndal, Sweden, were used as a reference. At the laboratory in Mölndal, the normal reference level for CSF amyloid-β42 is > 550 ng/L. The reference level for CSF T-tau is < 300 ng/L for individuals between 18 and 45 years of age and < 400 ng/L for those who are over 45 years old. CSF P-tau should be < 60 ng/L for those under 60 years of age and < 80 ng/L for those 60 years or older
