Cross-sectional associations of plasma vitamin D with cerebral β-amyloid in older adults at risk of dementia

Table 2 Exploration of the association of 25(OH)D with cerebral Aβ

Brain region	Unadjusted model			Adjusted model
Brain region	B coefficient	SE	p	B coefficient	SE	p
Cortex	− 0.001	0.001	0.587	− 0.001	0.001	0.376
Anterior cingulate	−0.001	0.002	0.378	−0.002	0.002	0.325
Anterior putamen	0.000	0.001	0.972	−0.000	0.001	0.880
Caudate	−0.001	0.001	0.502	−0.000	0.001	0.872
Hippocampus	0.000	0.001	0.840	0.001	0.001	0.495
Medial orbitofrontal cortex	−0.000	0.001	0.928	−0.000	0.001	0.794
Occipital cortex	−0.001	0.001	0.351	−0.001	0.001	0.291
Parietal cortex	−0.000	0.001	0.930	−0.001	0.001	0.662
Pons	0.000	0.001	0.941	0.000	0.001	0.698
Posterior cingulate	−0.000	0.001	0.779	−0.001	0.001	0.461
Posterior putamen	0.000	0.001	0.623	0.000	0.001	0.822
Precuneus	−0.001	0.002	0.471	−0.002	0.002	0.287
Temporal cortex	−0.001	0.001	0.479	−0.001	0.001	0.240
Semioval centre	−0.001	0.001	0.646	0.000	0.001	0.803

The unadjusted linear regression model in the main analysis included all 178 participants who underwent [¹⁸ F]-florbetapir positron emission tomography imaging. Cortical-to-cerebellar standard uptake value ratios were obtained using the mean signal of the following predefined cortical regions: frontal, temporal, parietal, precuneus, anterior cingulate and posterior cingulate. Other brain regions were independently assessed for Aβ in relation to the cerebellum as a reference region. The adjusted model contained fewer subjects (n = 176) due to missing data on confounders
Aβ beta-amyloid, 25(OH)D 25-hydroxyvitamin D, SE standard error

ISSN: 1758-9193