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Table 2 Exploration of the association of 25(OH)D with cerebral Aβ

From: Cross-sectional associations of plasma vitamin D with cerebral β-amyloid in older adults at risk of dementia

Brain region Unadjusted model Adjusted model
B coefficient SE p B coefficient SE p
Cortex − 0.001 0.001 0.587 − 0.001 0.001 0.376
Anterior cingulate −0.001 0.002 0.378 −0.002 0.002 0.325
Anterior putamen 0.000 0.001 0.972 −0.000 0.001 0.880
Caudate −0.001 0.001 0.502 −0.000 0.001 0.872
Hippocampus 0.000 0.001 0.840 0.001 0.001 0.495
Medial orbitofrontal cortex −0.000 0.001 0.928 −0.000 0.001 0.794
Occipital cortex −0.001 0.001 0.351 −0.001 0.001 0.291
Parietal cortex −0.000 0.001 0.930 −0.001 0.001 0.662
Pons 0.000 0.001 0.941 0.000 0.001 0.698
Posterior cingulate −0.000 0.001 0.779 −0.001 0.001 0.461
Posterior putamen 0.000 0.001 0.623 0.000 0.001 0.822
Precuneus −0.001 0.002 0.471 −0.002 0.002 0.287
Temporal cortex −0.001 0.001 0.479 −0.001 0.001 0.240
Semioval centre −0.001 0.001 0.646 0.000 0.001 0.803
  1. The unadjusted linear regression model in the main analysis included all 178 participants who underwent [18 F]-florbetapir positron emission tomography imaging. Cortical-to-cerebellar standard uptake value ratios were obtained using the mean signal of the following predefined cortical regions: frontal, temporal, parietal, precuneus, anterior cingulate and posterior cingulate. Other brain regions were independently assessed for Aβ in relation to the cerebellum as a reference region. The adjusted model contained fewer subjects (n = 176) due to missing data on confounders
  2. beta-amyloid, 25(OH)D 25-hydroxyvitamin D, SE standard error