Fig. 1
From: A biomarker study in long-lasting amnestic mild cognitive impairment
a and b Fluorodeoxyglucose-positron emission tomography (FDG-PET) hypometabolic patterns of two example subjects (i.e., statistical parametric mapping [SPM] single-subject analysis: 1 patient vs. 112 control subjects; p < 0.05, familywise error [FWE]-corrected at the voxel level with k > 100 voxels) representing (a) extensive hypometabolism in the medial temporal lobe (i.e., hippocampus and hippocampal structures) and limbic structures (amygdala, frontomedial cortex, and insula) and (b) selective medial temporal lobe hypometabolism, more extended on the left side. c and d FDG-PET hypometabolic pattern of the whole patient group (i.e., SPM one-sample group analysis; p < 0.05 FWE-corrected at the voxel level and p < 0.001 uncorrected at the voxel level, FWE-corrected at cluster level)