Table 2 Baseline patient and caregiver outcomes
Outcome | EXPEDITION RCTs (EU population) | GERAS observational study | p value for unadjusted baseline comparison |
|---|---|---|---|
Patients, N | 168 | 566 | |
29.4 (8.6) | 30.4 (7.8) | 0.16 | |
ADCS-ADL basic score (range 0–22 [13]) | 20.6 (2.5) | 19.8 (3.1) | 0.005 |
ADCS-ADL instrumental score (range 0–56 [13]) | 42.5 (9.9) | 38.5 (11.8) | < 0.001 |
12.0 (12.8) | 10.2 (10.7) | 0.07 | |
EQ-5D UK population-based index score (range 0–1 [16]) | 0.79 (0.18) | 0.71 (0.24) | < 0.001 |
EQ-5D VAS score (range 0–100 [16]) | 62.2 (24.1) | 66.0 (18.5) | 0.03 |
Caregivers, N | 168 | 566 | |
NPI-12 Caregiver Distress score (range 0–60 [15]) | 7.1 (7.1) | 6.4 (6.2) | 0.26 |
Caregiver time spent on patient (hours in past month) | |||
Basic ADL, mean (SD) | 9.8 (26.9) | 16.4 (44.7) | 0.009 |
Median (IQR) | 0 (0–0) | 0 (0–15) | |
Instrumental ADL, mean (SD) | 53.5 (61.9) | 61.0 (83.1) | 0.23 |
Median (IQR) | 30 (2–90) | 36 (8–90) | |
Supervision, mean (SD) | 24.9 (89.1) | 48.4 (123.6) | < 0.001 |
Median (IQR) | 0 (0–0) | 0 (0–30) | |
Overall, mean (SD) | 86.3 (128.5) | 121.6 (174.2) | 0.01 |
Median (IQR) | 30.6 (3–120) | 60 (15–125) | |