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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer’s disease, whereas amyloid deposition does not

Fig. 3

Brain amyloid deposition does not significantly correlate with thiamine diphosphate (TDP) level. a Representative image of positive scan obtained by positron emission tomography with 11C-Pittsburgh compound B in patients with Alzheimer’s disease (AD). b–d Blood TDP levels did not closely correlate with average standardized uptake value ratios (SUVRs) of representative brain regions in patients with AD (P > 0.05; n = 35). e–h Comparison of the levels of blood (e, g) and brain (f, h) thiamine metabolites between 6-month-old (e, f) or 10- to 12-month old (g, h) amyloid precursor protein/presenilin-1 (APP/PS1) transgenic and age-matched wild-type (WT) mice (all P > 0.05; n = 12 for each group)

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Alzheimer's Research & Therapy

ISSN: 1758-9193