Skip to main content


Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer’s disease

Fig. 4

Association between inflammatory markers and cognitive performance in Alzheimer’s disease (AD). Six significant correlations were robust in multivariable linear regression analysis adjusting for age, sex, and education (see Additional file 2). Correlations (a) between the total sum of the Free and Cued Selective Reminding Test (FCSRT sum) and macrophage migration inhibitory factor (MIF), (b) between semantic fluency and vascular endothelial growth factor (VEGF), and between (c) phonetic fluency and VEGF, (d) C-reactive protein (CRP), (e) soluble intercellular adhesion molecule 1 (sICAM-1), and (f) C3aDesArg. Phonetic fluency was the most prominent cognitive correlate. In all cases, higher levels of inflammatory markers in the cerebrospinal fluid were associated with lower cognitive performance

Back to article page