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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer’s disease

Fig. 3

Correlation matrix of the main cohorts depicting results of nonparametric Spearman’s correlations, visualized by plotting significance values (p, lower left) against strength of correlation (r, upper right) as a heat map. In general, there were a large number of highly significant correlations of weak or moderate strength: (1) correlation of standard Alzheimer’s disease (AD) markers with each other, (2) cerebrospinal fluid (CSF) total protein and inflammatory markers against each other, (3) neuropsychiatric tests (NPTs) against each other, (4) AD markers against inflammatory markers, (5) AD markers against NPT results, (6) inflammatory markers against NPT results, and (7) and (8) influence of patient age and biobank storage time. 40 β-Amyloid 1–40, 42 β-Amyloid 1–42, CRP C-reactive protein, FCSRT Free and Cued Selective Reminding Test, IgG Immunoglobulin G, IL Interleukin, IP-10 Interferon-γ-induced protein 10, MCP-1 Monocyte chemoattractant protein 1, MIF Macrophage migration inhibitory factor, MMSE Mini Mental State Examination, p-tau-181 Tau phosphorylated at position 181, SAA Serum amyloid A protein, sICAM-1 Soluble intercellular adhesion molecule 1, sIL-1RAcP Soluble inhibition of soluble interleukin-1 receptor accessory protein, sTREM2 Soluble triggering receptor expressed on myeloid cells 2, sVCAM-1 Soluble vascular cell adhesion molecule 1, TMT Trail Making Test, t-tau Total tau, VEGF Vascular endothelial growth factor, VEGFR Vascular endothelial growth factor receptor

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