Skip to main content

Table 3 Results of differential gene expression analysis in brain

From: Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease

  RNA-Seq Microarray
CER TCX CER DLPFC VCX
Gene β value (SE) P value β value (SE) P value β value (SE) P value β value (SE) P value β value (SE) P value
ECRG4 a 0.06 (0.20) 0.77 0.19 (0.24) 0.43 −0.18 (0.05) 1.6 × 10 −3 −0.12 (0.06) 0.04 −0.12 (0.04) 2.7 × 10−3
HDAC9 −0.24 (0.12) 0.04 −0.31 (0.08) 1.5 × 10 −4 −0.01 (0.02) 0.77 −0.09 (0.03) 7.9 × 10−3 −0.06 (0.02) 5.6 × 10 −4
TRAPPC12 −0.05 (0.06) 0.35 −0.13 (0.05) 0.01 −0.09 (0.03) 1.1 × 10 −3 −0.03 (0.02) 0.09 −0.08 (0.02) 3.2 × 10 −4
TRAPPC12-AS1 0.22 (0.12) 0.06 0.59 (0.18) 1.3 × 10 −3
ADI1 −0.10 (0.08) 0.19 −0.07 (0.08) 0.36 −0.10 (0.03) 4.9 × 10 −4 −0.03 (0.03) 0.31 −0.01 (0.03) 0.64
  1. Abbreviations: CER Cerebellum, TCX Temporal cortex, DLPFC Dorsolateral prefrontal cortex, CER Cerebellum, TCX Temporal cortex, DLPFC Dorsolateral prefrontal cortex, VCX Visual cortex
  2. Results were obtained from analyses of RNA-Seq data in the Synapse database (https://www.synapse.org; [17]) and microarray data in the Gene Expression Omnibus database [GEO:GSE44771]. Negative β value indicates lower level of gene expression in AD cases compared with controls and vice versa. Results that remained significant after multiple test correction (P = 0.05/22 = 2.27 × 10−3) are highlighted in bold
  3. aAlso known as C2orf40