Table 1 Genome-wide significant association (P < 5.0 × 10−8) of novel genes in the genome-wide pleiotropy analyses (joint models) of the three neuropathological traits neuritic plaque, neurofibrillary tangles, and cerebral amyloid angiopathy
From: Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease
Univariate models | Joint models | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AD status | NP | NFT | CAA | NP + NFT | NP + CAA | NFT + CAA | |||||||||||||
Chromosome | SNP | Gene | EA | RA | EAF | β value (SE) | P value | β value (SE) | P value | β value (SE) | P value | β value (SE) | P value | Direction | P value | Direction | P value | Direction | P value |
2 | rs34487851 | ECRG4 a | G | A | 0.27 | −0.42 (0.09) | 5.8 × 10−6 | −0.3 (0.06) | 7.7 × 10−7 | −0.25 (0.06) | 4.5 × 10−6 | −0.14 (0.08) | 0.06 | − | 2.0 × 10−8 | − | 2.5 × 10−6 | − | 2.1 × 10−5 |
7 | rs79524815 | HDAC9 | G | T | 0.03 | 0.69 (0.31) | 0.03 | 0.43 (0.19) | 0.03 | 0.79 (0.19) | 2.3 × 10−5 | 1.16 (0.26) | 9.1 × 10−6 | + | 1.3 × 10−4 | + | 3.3 × 10−6 | + | 1.1 × 10−8 |