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Table 1 Genome-wide significant association (P < 5.0 × 10−8) of novel genes in the genome-wide pleiotropy analyses (joint models) of the three neuropathological traits neuritic plaque, neurofibrillary tangles, and cerebral amyloid angiopathy

From: Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease

       Univariate models Joint models
AD status NP NFT CAA NP + NFT NP + CAA NFT + CAA
Chromosome SNP Gene EA RA EAF β value (SE) P value β value (SE) P value β value (SE) P value β value (SE) P value Direction P value Direction P value Direction P value
2 rs34487851 ECRG4 a G A 0.27 −0.42 (0.09) 5.8 × 10−6 −0.3 (0.06) 7.7 × 10−7 −0.25 (0.06) 4.5 × 10−6 −0.14 (0.08) 0.06 2.0 × 10−8 2.5 × 10−6 2.1 × 10−5
7 rs79524815 HDAC9 G T 0.03 0.69 (0.31) 0.03 0.43 (0.19) 0.03 0.79 (0.19) 2.3 × 10−5 1.16 (0.26) 9.1 × 10−6 + 1.3 × 10−4 + 3.3 × 10−6 + 1.1 × 10−8
  1. Abbreviations: EA Effect allele, RA Reference allele, EAF Effect allele frequency, SNP Single-nucleotide polymorphism, AD Alzheimer’s disease, NP Neuritic plaque, NFT Neurofibrillary tangles, CAA Cerebral amyloid angiopathy
  2. aAlso known as C2orf40