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Table 4 Significant Relationships between peak cluster volumes and clinical parameters (Bcl-2 G-carriers)

From: Associations of Bcl-2 rs956572 genotype groups in the structural covariance network in early-stage Alzheimer’s disease

Seed region EC PCC PCC PCC dLPFC
Peak cluster Superior frontal cerebellum cerebellum Sub-lobar Superior frontal
Covariance strength relationship G < AA G > AA G > AA G < AA G < AA
MNI coordinate (12,14,57) (-33,-57,-21) (-23,-55,-20) (-23,8,14) (14,41,39)
Mini-mental state examination 0.017 0.340 0.261 a -0.171 -0.227 a
T1 to T4 trial scores -0.108 0.374 b 0.291 a -0.159 -0.112
30 second recalls -0.049 0.362 b 0.193 -0.104 -0.112
10 minute recalls -0.037 0.259 a 0.197 -0.087 -0.192
Modified Rey-Osterrieth Recall -0.040 0.273 a 0.177 -0.056 -0.118
Modified Rey-Osterrieth Copy -0.115 0.270 a 0.181 -0.020 -0.090
Visual object and Space Perception -0.009 0.178 -0.007 -0.059 -0.084
Semantic fluency: Animal -0.119 0.256 a 0.161 -0.083 -0.206
Boston Naming Test 0.093 0.374 b 0.214 -0.073 -0.144
Comprehension -0.045 0.317 b 0.321 b -0.420 b -0.148
Digit backward 0.006 0.268 0.198 -0.240 a -0.112
Stroop Interference Correct -0.255 a 0.234 0.152 -0.085 -0.118
Design fluency 0.058 0.228 0.049 -0.015 -0.113
Trail making test time 0.066 -0.230 a -0.076 0.201 0.194
Correct line in Trail making -0.139 0.286 a 0.181 -0.163 -0.074
Neuropsychiatric Inventory -0.068 -0.050 -0.064 -0.042 0.197
  1. Numbers indicate Spearman correlation coefficient; ap < 0.05; b p <0.01; EC entorinal cortex, PCC posterior cingulate cortex, dLPFC dorsolateral prefrontal cortex