Table 1 Baseline characteristics
Safety/ITT population (N = 24) | ||
|---|---|---|
ABvac40 (n = 16) | Placebo (n = 8) | |
Age, years | ||
Mean (SD) | 72.4 (7.2) | 62.8 (6.9) |
Years of education | ||
Mean (SD) | 7.1 (3.4) | 8.9 (5.4) |
Sex | ||
Male | 8 (50%) | 3 (38%) |
Female | 8 (50%) | 5 (63%) |
Time from AD diagnosis, months | ||
Mean (SD) | 18.3 (17.4) | 13.0 (11.7) |
APOE genotype | ||
ε3ε3 | 6 (38%) | 3 (38%) |
ε3ε4 | 8 (50%) | 3 (38%) |
ε4ε4 | 2 (13%) | 2 (25%) |
GDS | ||
0–10: Normal | 15 (94%) | 8 (100%) |
11–14: Depression | 1 (6%) | 0 (0%) |
> 14: Depression | 0 (0%) | 0 (0%) |
Hachinski Ischemic Scale score | ||
< 4 Suggestive of degenerative disorder | 16 (100%) | 8 (100%) |
4–7 Doubtful cases and mixed dementias | 0 (0%) | 0 (0%) |
> 7 Suggestive of vascular involvement | 0 (0%) | 0 (0%) |
Leukoaraiosis scale, total | ||
Mean (SD) | 2.8 (2.7) | 2.6 (4.1) |
Microhaemorrhage presence | ||
Yes | 4 (25%) | 2 (25%) |
CDR | ||
0.5 points | 2 (13%) | 4 (50%) |
1 point | 14 (88%) | 4 (50%) |
2 points | 0 (0%) | 0 (0%) |
MMSE total score | ||
Mean (SD) | 19.0 (2.7) | 21.2 (3.4) |
MMSE total score (by age and schooling) | ||
Mean (SD) | 20.1 (2.7) | 21.9 (3.3) |