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Table 1 Clinical, laboratory and electroencephalographic features of cases classified as atypical/rapidly progressive neurodegenerative dementia

From: The CSF neurofilament light signature in rapidly progressive neurodegenerative dementias

 

a/rpAD

a/rpDLB

a/rpFTLD

No. of subjects

37

11

9

Clinical presentation

 Cognitive decline

37/37

11/11

9/9

 Extrapyramidal signs

5/37

11/11

3/9

 Pyramidal signs

3/37

0/11

1/9

 Myoclonus

5/37

3/11

3/9

 Akinetic mutism

5/37

1/11

2/9

Biomarker data

 t-tau > 1100 pg/ml

19/37

5/10

2/9

 Positive 14-3-3

4/37

3/10

1/9

EEG PSWC

5/37

4/11

1/9

  1. Abbreviations: AD Alzheimer’s disease, a/rp Atypical/rapidly progressive, DLB Dementia with Lewy bodies, EEG Electroencephalographic, FTLD Frontotemporal lobar degeneration, PSWC Periodic sharp wave complexes, t-tau Total tau protein
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Alzheimer's Research & Therapy

ISSN: 1758-9193