Fig. 3

Neuropathology. Photomicrographs of cortical, white matter, and hippocampal sections from three family members. Individuals, immunohistochemistry, and enlargement are as indicated. All three patients had abundant tau pathology in the cortex and white matter, with a marked predominance of four-repeat (exon 10+) tau isoform immunoreactivity. 3R tau Three-repeat (exon 10−) tau isoform. 4R tau Four-repeat (exon 10+) tau isoform