Fig. 1

Pedigree of a novel Swedish family with MAPT R406W mutation. Circles denote females, squares represent males, and diamonds indicate that sex was disguised; a diagonal line indicates a deceased family member; sibling order was changed, and in some branches, “n” indicates that the number of siblings is not specified, both to protect the family’s confidentiality. Solid black symbol indicates individuals with dementia with age at onset before 71 years; half-filled symbols indicate dementia with a later age at onset or that clinical information was ambiguous. Mut R406W mutation detected by genetic testing, (Mut) Obligate R406W carrier, Wt Wild type (i.e., R406W mutation excluded by genetic testing). Additional individuals were tested genetically (not shown)