A selenium species in cerebrospinal fluid predicts conversion to Alzheimer’s dementia in persons with mild cognitive impairment

Table 4 Crude and adjusted HR of developing Alzheimer’s dementia in a Cox proportional hazards model, comparing participants with baseline selenium CSF concentrations above versus below (reference) the median value

Se species	Crude		Adjusted^a		Adjusted^b
Se species	HR	95% CI	HR	95% CI	HR	95% CI
Total Se	1.6	(0.7–3.9)	1.5	(0.6–3.8)	2.0	(0.7–5.9)
Inorganic Se	0.8	(0.3–1.9)	1.2	(0.5–3.0)	1.0	(0.4–2.9)
Se(IV)	0.6	(0.2–1.4)	0.7	(0.3–1.7)	0.8	(0.3–2.2)
Se(VI)	2.6	(1.0–6.7)	3.1	(1.0–9.5)	2.4	(0.7–7.8)
Organic Se	1.4	(0.6–3.3)	0.9	(0.3–2.4)	1.0	(0.3–2.8)
Se-SelenoP	1.3	(0.6–3.2)	0.9	(0.3–2.3)	1.0	(0.3–2.8)
Se-Met	1.3	(0.5–3.0)	1.2	(0.5–3.0)	2.3	(0.9–5.9)
Se-Cys	0.6	(0.2–1.9)	0.6	(0.2–1.9)	0.6	(0.2–2.2)
Se-GPX	1.1	(0.5–2.6)	1.0	(0.4–2.5)	0.8	(0.3–2.2)
Se-HSA	1.2	(0.5–2.9)	1.3	(0.5–3.5)	1.7	(0.5–5.3)
Unknown	1.0	(0.4–2.4)	2.7	(0.8–9.3)	4.1	(0.9–18.8)

CI confidence interval, CSF cerebrospinal fluid, HR hazard ratio, MCI mild cognitive impairment, Se selenium, Se(IV) selenite, Se(VI) selenate, Se-SelenoP selenoprotein P-bound Se, Se-Met selenomethionine-bound Se, Se-Cys selenocysteine-bound Se, Se-GPX glutathione-peroxidase-bound Se, Se-HSA human serum albumin selenium-bound Se
^aAdjusted for sex, age at entry, years of storage, and years of education
^bAdjusted for sex, age at entry, years of storage, years of education, and β-amyloid and phosphorylated tau protein level

ISSN: 1758-9193